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Prenatal direct exposure to destitution influences long-lasting health

.Nature Medicine, Posted online: 09 September 2024 doi:10.1038/ d41591-024-00068-4Analysis of record...

A worldwide metric of immune wellness

.Nature Medication, Published online: 05 September 2024 doi:10.1038/ s41591-024-03210-4A research us...

Niacin, meals intake and also cardio effects

.Nature Medicine, Posted online: 05 September 2024 doi:10.1038/ s41591-024-03220-2Niacin, food items...

Opportunities and also challenges for patient-reported result analysis in multimorbidity research study as well as technique

.Completing rate of interests.S.E.H. acquires backing from the National Principle of Wellness and Tr...

Hibernation scientific research utilized to manage obesity and modify rate of metabolism

.Attributes Medication, Published online: 04 September 2024 doi:10.1038/ s41591-024-03226-wBy recogn...

CAR- T and also cell genetics treatments are actually too costly

.Mother Nature Medication, Posted online: 04 September 2024 doi:10.1038/ s41591-024-03231-zPoint-of-...

The that genomics plan of help reasonable execution of human genomics for global health and wellness

.The publication of the first draft of the individual genome pattern in 20011 was actually followed ...

Advancing global antibiotic analysis, growth and gain access to #.\n\nMurray, C. J. L. et cetera. Worldwide trouble of bacterial antimicrobial protection in 2019: a systematic analysis. Lancet 399, 629\u00e2 $ \"655 (2022 ). AMR Frontrunnerses. In the direction of certain devotions and action in the action to antimicrobial protection. Global Frontrunners Team on Antimicrobial Resistance https:\/\/www.amrleaders.org\/resources\/m\/item\/glg-report (4 April 2024). Globe Health Organization. That publishes checklist of microorganisms for which brand-new prescription antibiotics are actually quickly needed. Planet Health and wellness Company https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed (27 February 2017). World Health And Wellness Company. That microbial priority virus checklist, 2024: bacterial virus of hygienics usefulness to direct analysis, development and techniques to avoid and manage antimicrobial protection. Globe Health and wellness Company https:\/\/www.who.int\/publications\/i\/item\/9789240093461 (17 May 2024). Silver, L. L. A Gestalt approach to Gram-negative access. Bioorg. Med. Chem. 24, 6379\u00e2 $ \"6389 (2016 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nSundqvist, M. Reversibility of antibiotic protection. Ups. J. Medication. Sci. 119, 142\u00e2 $ \"148 (2014 ).\nGoogle Scholar\u00c2.\nPlanet Health Company. 2023 antibacterial brokers in scientific as well as preclinical development: an outline and analysis. Globe Health and wellness Organization https:\/\/www.who.int\/publications\/i\/item\/9789240094000 (14 June 2024). O' Neill, J. et cetera. AMR Customer review. May 19, 2016 \u00e2 $\" Taking on drug-resistant infections globally: last record and referrals. Evaluation on Antimicrobial Resistance https:\/\/amr-review.org\/Publications.html (19 May 2016). Drive-AB Range. DRIVE-AB outcomes: files as well as rundown. Drive abdominal muscle https:\/\/drive-ab.eu\/drive-ab-outputs\/drive-ab-reports\/ (2016 ). Stern, S. et cetera. Breaking through the wall structure: a require concurrent action on anti-biotics r &amp d. Boston ma Consulting Group https:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/Dateien\/5_Publikationen\/Gesundheit\/Berichte\/GUARD_Follow_Up_Report_Full_Report_final.pdf (February, 2017). Anderson, M., Panteli, D. &amp Mossialos, E. Policy Concise 51: How can the EU help maintainable technology and access to helpful anti-biotics? policy possibilities for existing as well as new medicines. International Observatory on Health Systems and also Plans https:\/\/eurohealthobservatory.who.int\/publications\/i\/how-can-the-eu-support-sustainable-innovation-and-access-to-effective-antibiotics-policy-options-for-existing-and-new-medicines (21 June 2023). Turnidge, J. &amp Christiansen, K. Prescription antibiotic use as well as resistance\u00e2 $\" proving the apparent. Lancet 365, 548\u00e2 $ \"549 (2005 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nWorld Wellness Institution. 2021 Informed distinction. That accessibility, watch, get, distinction of anti-biotics for assessment as well as monitoring of use. Planet Health and wellness Association https:\/\/www.who.int\/publications\/i\/item\/2021-aware-classification (30 September 2021). International Center for Ailment Avoidance and Management. Antimicrobial protection intendeds: how can our experts reach them through 2030? ECDC https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/amr-brief-eaad-2023-update.pdf (2023 ). World Wellness Organization. Absence of advancement readied to undermine antibiotic functionality as well as health and wellness increases. World Health Organization https:\/\/www.who.int\/news\/item\/22-06-2022-22-06-2022-lack-of-innovation-set-to-undermine-antibiotic-performance-and-health-gains (22 June 2022). Magnano San, L. R. et cetera. Just how antimicrobial resistance is linked to environment modification: an outline of pair of linked international obstacles. Int. J. Environ. Res. Hygienics twenty, 1681 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nDolecek, C., Shakoor, S., Basnyat, B., Okwor, T. &amp Sartorius, B. Drug-resistant microbial infections: our experts require critical action and also expenditure that pay attention to the weakest web link. PLoS Biol. 20, e3001903 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nGlobe Health And Wellness Organization. Immunization protection. Planet Wellness Institution https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/immunization-coverage (15 July 2024). Chimhini, G., Magwenzi, M. &amp Fitzgerald, F. C. Disease avoidance as well as command in low-resource environments: the need for the local, the contextual as well as the pragmatic. Contaminate. Prev. Pract. 4, 100135 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNour, S., Stokle, E., Ashiru-Oredope, D. &amp Wesangulae, E. Challenges of implementing antimicrobial conservation devices in low to middle earnings countries (LMICs). Contaminate. Prev. Pract. 5, 100315 (2023 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nAminov, R. A short past of the antibiotic period: trainings knew and also problems for the future. Front end. Microbiol. 1, 134 (2010 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nOutterson, K. et al. Client accessibility in 14 high-income nations to brand-new antibacterials authorized by the United States Food and Drug Administration, European Medicines Company, Japanese Pharmaceuticals and Medical Equipment Company, or Health And Wellness Canada, 2010\u00e2 $ \"2020. Clin. Corrupt. Dis. 74, 1183\u00e2 $ \"1190 (2022 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nGlobe Health Company. 2021 anti-bacterial representatives in medical and also preclinical development: a guide and study. Globe Health and wellness Organization https:\/\/www.who.int\/publications\/i\/item\/9789240047655 (27 May 2022). Anti-biotics: the business economics have to assist the science. Nature 625, 7 (2024 ). Thomas, D. &amp Wessel, C. The state of technology in anti-bacterial therapies. Medical Technology Association https:\/\/www.bio.org\/sites\/default\/files\/2022-02\/The-State-of-Innovation-in-Antibacterial-Therapeutics.pdf (February, 2022). Strich, J. et al. Evaluating specialist usage of next-generation anti-biotics versus insusceptible Gram-negative diseases in united state medical centers: a retrospective associate research study. Ann. Trainee. Med. 177, 559\u00e2 $ \"572 (2024 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nThomas, D. &amp Wessel, C. The state of technology in antibacterial therapeutics. Biotechnology Technology Institution https:\/\/www.bio.org\/sites\/default\/files\/2022-04\/BIO-Antibacterial-Report-2022.pdf (February 2022). Renwick, M. J., Brogan, D. M. &amp Mossialos, E. A systematic review and crucial evaluation of reward methods for revelation as well as progression of unique prescription antibiotics. J. Antibiot. 69, 73\u00e2 $ \"88 (2016 ). Article\u00c2.\nCAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nHealth And Wellness Urgent Preparedness and also Action Authorization. Trial and error of medical countermeasures. European Percentage https:\/\/health.ec.europa.eu\/health-emergency-preparedness-and-response-hera\/preparedness\/research-and-development-medical-countermeasures_en (2024 ). International Commission. Pre-draft proposition for an European partnership under Perspective Europe One Health And Wellness Antimicrobial Resistance. European Compensation https:\/\/research-and-innovation.ec.europa.eu\/system\/files\/2022-02\/ec_rtd_he-partnerships-onehealth-amr.pdf (9 February 2022). Global Antibiotic Experimentation Alliance. Entasis Therapeutics and also the International Antibiotic Research Study &amp Advancement Relationship to create a brand new therapy for gonorrhea. GARDP https:\/\/gardp.org\/entasis-therapeutics-and-the-global-antibiotic-research-development-partnership-to-develop-a-new-treatment-for-gonorrhea\/ (6 July 2017). Atal, I., Trinquart, L., Porcher, R. &amp Ravaud, P. Differential globalization of field- as well as non-industry-sponsored clinical trials. PLoS ONE 10, e0145122 (2015 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nGlobe Health And Wellness Company. Variety of professional trial signs up through location, disease, phase of growth, age and sexual activity of trial participants (1999\u00e2 $ \"2022). World Health and wellness Organization https:\/\/www.who.int\/observatories\/global-observatory-on-health-research-and-development\/monitoring\/number-of-trial-registrations-by-year-location-disease-and-phase-of-development (February 2023). Global Prescription Antibiotic R &amp D Relationship. NeoSept1: a research to find out the ranking of existing and brand-new antibiotics combos to treat newborns that are in healthcare facility with serious sepsis. ISRCTN pc registry https:\/\/www.isrctn.com\/ISRCTN48721236 (17 January 2022). Public Health Organization of Canada. Federal government of Canada brings in necessary financial investment to fight antimicrobial resistance (AMR), Federal government of Canada https:\/\/www.canada.ca\/en\/public-health\/news\/2023\/05\/government-of-canada-makes-important-investment-to-fight-antimicrobial-resistance-amr.html (11 May 2023). Global Prescription Antibiotic Research and Development Relationship. Asia authorities backing assists GARDP\u00e2 $ s initiatives to respond to antibiotic protection. GARDP https:\/\/gardp.org\/japan-government-funding-supports-gardps-efforts-to-counter-antibiotic-resistance\/ (19 Oct 2023). Novo Nordisk Structure. Novo Nordisk Groundwork companions with CARB-X to overcome drug-resistant contaminations. novo nordisk structure https:\/\/novonordiskfonden.dk\/en\/news\/novo-nordisk-foundation-partners-with-carb-x-to-fight-drug-resistant-infections\/ (9 January 2024). International Commission: European Health and also Digital Exec Company. Research study on delivering AMR medical countermeasures to the market place. Publications Office of the European Union https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/51b2c82c-c21b-11ed-8912-01aa75ed71a1\/language-en (2023 ). Outterson, K. Approximating the suitable dimension of international pull incentives for antibacterial medicines. Health Aff. 40, 1758\u00e2 $ \"1765 (2021 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nEvans, E. J., Meyer, A. &amp Conti, R. M. Sizing a market entrance benefit for the advancement of brand-new prescription antibiotics. Harvard Kennedy Institution https:\/\/www.hks.harvard.edu\/sites\/default\/files\/centers\/mrcbg\/Final_AWP_232.pdf (May 2024). Morel, C. M. et al. Sector motivations as well as antibiotic resistance: an overview to the antibiotic vulnerability perk. J. Antibiot. 73, 421\u00e2 $ \"428 (2020 ). CAS\u00c2.\n\nGoogle Scholar\u00c2.\nBonnifield, R. &amp Towse, A. An ambitious USG advanced dedication for subscription-based acquiring of unique antimicrobials and also its own assumed return on investment. Facility for Global Progression https:\/\/www.cgdev.org\/publication\/ambitious-usg-advanced-commitment-subscription-based-purchasing-novel-antimicrobials (15 Nov 2022). Towse, A. &amp Silverman Bonnifield, R. G7 assets in brand new prescription antibiotics will pay \u00e2 $\" for everybody. Office of Wellness Business economics https:\/\/www.ohe.org\/insight\/g7-investments-in-new-antibiotics-would-pay-off-for-everyone\/ (9 December 2022). NHS England. NHS boosts struggle versus severe diseases observing successful world-first captain. NHS England https:\/\/www.england.nhs.uk\/2023\/07\/nhs-steps-up-battle-against-life-threatening-infections-following-successful-world-first-pilot\/ (11 July 2023). United States Congress. S. 1355 \u00e2 $\" PASTEUR Action of 2023. congress.gov www.congress.gov\/bill\/118th-congress\/senate-bill\/1355#:~:text=This%20bill%20authorizes%20the%20Department,and%20contains%20other%20related%20provisions (27 April 2023). International Commission. Reform of the EU pharmaceutical legalisation. International Percentage https:\/\/health.ec.europa.eu\/medicinal-products\/pharmaceutical-strategy-europe\/reform-eu-pharmaceutical-legislation_en (26 April 2023). Gotham, D. et cetera. Compensation designs to tackle market failings for antimicrobials: methods consumed France, Germany, Sweden, the United Kingdom, as well as the United States. Health and wellness Policy 125, 296\u00e2 $ \"306 (2020 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nInternational Federation of Pharmaceutical Manufacturers and Associations. From resistance to durability: what could the potential antibiotic pipe look like? IFMPA https:\/\/www.ifpma.org\/publications\/from-resistance-to-resilience-what-could-the-future-antibiotic-pipeline-look-like\/ (14 May 2024). Worldwide AMR R&ampD Center &amp World Health And Wellness Association. Incentivising the advancement of new anti-bacterial treatments: 2023 report card by the Global AMR R&ampD Hub and also That. International AMR R&ampD Hub https:\/\/globalamrhub.org\/publications\/incentivising-the-development-of-new-antibacterial-treatments-2023\/ (2023 ). Glover, R. E., Performer, A., Roberts, A. P. &amp Kirchhelle, C. Why is the UK subscription version for antibiotics considered prosperous? Lancet Microbe 4, e852\u00e2 $ \"e853 (2023 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nNon-paper \u00e2 $\" unfamiliar stimuli for the development and also keeping on the market place of antimicrobials. Politician https:\/\/www.politico.eu\/wp-content\/uploads\/2022\/12\/01\/Non-paper-Transferable-exclusivity-voucher-for-AMR-2.pdf (2022 ). Liu, L. et al. Global, regional, and nationwide root causes of youngster death in 2000\u00e2 $ \"thirteen, along with projections to notify post-2015 concerns: an updated step-by-step analysis. Lancet 385, 430\u00e2 $ \"440 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nQuadri, F. et al. Antibacterial medication lacks from 2001 to 2013: implications for clinical practice. Clin. Infect. Dis. 60, 1737\u00e2 $ \"1742 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nBenhabib, A. et al. The French reporting device for medication deficiencies: summary and trends coming from 2012 to 2018: an observational retrospective study. BMJ Open 10, e034033 (2020 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nKlein, E. Y. et cetera. Examination of WHO antibiotic consumption as well as accessibility aim ats in 76 countries, 2000\u00e2 $ \"15: a study of pharmaceutical sales information. Lancet Infect. Dis. 21, 107\u00e2 $ \"115 (2021 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nPyzik, O. Z. &amp Abubakar, I. Battling the fakes: dealing with low quality as well as falsified medications. Nat. Rev. Dis. Primers 8, 55 (2022 ). Hayhoe, B., Greenfield, G. &amp Majeed, A. Is it receiving much easier to obtain antibiotics in the UK? Br. J. Gen. Pract. 69, 54\u00e2 $ \"55 (2019 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nBlack Community for Research Laboratory Medication. Policy concise and also infographics on antimicrobial protection (AMR) in Africa. ASLM https:\/\/aslm.org\/resource\/policy-brief-and-infographics-on-antimicrobial-resistance-amr-in-africa\/ (14 September 2022). Kanu, J. S. et cetera. National antibiotic consumption for individual usage in Sierra Leone (2017\u00e2 $ \"2019): a cross-sectional research. Trop. Medication. Affect. Dis. 6, 77 (2021 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nNamugambe, J. S. et al. National antimicrobial intake: study of core storage facilities supplies to in-patient treatment health and wellness locations coming from 2017 to 2019 in Uganda. Trop. Med. Corrupt. Dis. 6, 83 (2021 ).\nGoogle.com Scholar\u00c2.\nRobertson, J. et al. Varieties in the consumption of antimicrobial medicines in the European region, 2014\u00e2 $ \"2018: findings as well as effects coming from ESAC-Net and also WHO Europe. Face. Pharmacol. 12, 639207 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nShukar, S. et cetera. Medication scarcity: causes, impact, and also relief methods. Face. Pharmacol. 12, 693426 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nOutterson, K., Orubu, E. S. F., Rex, J., \u00c3 ... rdal, C. &amp Zaman, M. H. Person get access to in 14 high-income countries to brand new antibacterials approved due to the US Food and Drug Administration, European Medicines Company, Japanese Pharmaceuticals and also Medical Devices Agency, or Health And Wellness Canada, 2010\u00e2 $ \"2020. Clin. Infect. Dis. 74, 1183\u00e2 $ \"1190 (2021 ). Article\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nPulcini, C. et al. Lost antibiotics: a follow-up supply research in Europe, the U.S.A., Canada as well as Australia. Int. J. Antimicrob. Brokers 49, 98\u00e2 $ \"101 (2017 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nRottingen, J. A. &amp Farrar, J. Targeted wellness technology for worldwide wellness. Br. Medication. J. 366, 15601 (2019 ).\nGoogle.com Scholar\u00c2.\nAMR Market Alliance. The 2023 AMR Field Alliance development questionnaire: manufacturing and the setting. amr Market Partnership https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/12\/AMRIA_Manufacturing-and-the-environment-FINAL.pdf (2023 ). Munoz, V., Visentin, F., Venture, D. &amp Gaule, P. Can clinical products be actually developed on a charitable manner? Discovering product progression alliances for overlooked ailments. Sci. Public Policy 42, 315\u00e2 $ \"338 (2015 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nSwaminathan, S. et al. Reboot biomedical R&ampD in the global public passion. Nature 602, 207\u00e2 $ \"210 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nAfrica Centres for Ailment Command as well as Protection. Africa CDC spearheads vibrant move to get Africa\u00e2 $ s health future by developing a 50 billion buck health care market. AfricaCDC https:\/\/africacdc.org\/news-item\/africa-cdc-spearheads-bold-move-to-secure-africas-health-future-by-creating-a-50-billion-dollar-medical-market\/ (19 February 2024). Gore, C., Morin, S., R\u00c3 \u00b8 ttingen, J. A. &amp Kieny, M. P. Haggling public-health copyright licensing deals to boost accessibility to health and wellness modern technologies: an insider\u00e2 $ s story. BMJ Chunk. Wellness 8, e012964 (2023 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nSuleman, F., Low, M., Moon, S. &amp Morgan, S. G. New business designs for experimentation along with affordability demands are needed to have to attain decent rates of medications. Br. Med. J. 368, l4408 (2020 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nCombating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator. Conservation as well as accessibility. CARB-X https:\/\/carb-x.org\/about\/stewardship-and-access\/ (2024 ). Global Antibiotic Trial And Error Relationship. Shinogi, GARDP and CHAI introduce landmark certificate and partnership arrangements to treat microbial diseases by broadening accessibility to cefiderocol in 135 nations. GARDP https:\/\/gardp.org\/shionogi-gardp-and-chai-announce-landmark-license-and-collaboration-agreements-to-treat-bacterial-infections-by-expanding-access-to-cefiderocol-in-135-countries\/ (15 June 2022). AMR Market Partnership. Leaving behind the laboratory: tracking the decrease in AMR R&ampD professionals. amr Industry Collaboration https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/02\/Leaving-the-Lab_final-1.pdf (February, 2024). G7 Health Ministers. G7 Health Ministers\u00e2 $ Communiqu\u00c3 \u00a9. G7 Germany www.g7germany.de\/resource\/blob\/974430\/2042058\/5651daa321517b089cdccfaffd1e37a1\/2022-05-20-g7-health-ministers-communique-data.pdf (twenty May 2022). G20. G20 contact us to activity on antimicrobial protection. G7G20 Files Data bank https:\/\/g7g20-documents.org\/database\/document\/2022-g20-indonesia-sherpa-track-health-ministers-ministers-annex-g20-call-to-action-on-antimicrobial-resistance (28 October 2022). Global Union on Growing Old &amp Contagious Ailments Community of The United States. 2024 AMR readiness index report card. Determining authorities activity on AMR plan. Global Coalition on Aging https:\/\/globalcoalitiononaging.com\/wp-content\/uploads\/2024\/01\/2024-AMR-Index-Progress-Report.pdf (2024 ). Food Items and also Farming Organization of the United Nations, United Nations Environment Program, World Wellness Organization &amp. Planet Organization for Pet Health And Wellness. Worldwide data source for tracking antimicrobial resistance (AMR): nation self-assessment questionnaire (TrACSS). WHO https:\/\/amrcountryprogress.org\/

/map-viewindicator2.3 (2023 ). Vehicle Katwyk, S. R. &amp Outterson K. Introduction: AMR belongs in ...

Integrating liver endpoints in medical trials of cardiovascular and also kidney health condition

.Nature Medicine, Posted online: 03 September 2024 doi:10.1038/ s41591-024-03223-zThis Standpoint as...